UFC 334 Odds: Ciryl Gane, Kayla Harrison Favored at Madison Square Garden

UFC 334 is shaping up as one of the UFC’s biggest cards of 2026, with heavyweight champion Ciryl Gane defending against undefeated Josh Hokit and Kayla Harrison putting her women’s bantamweight title on the line against former two-division champion Amanda Nunes.

The UFC will return to Madison Square Garden in New York City on November 14, 2026, with two championship fights anchoring the card. The latest UFC 334 betting lines have Gane and Harrison listed as favorites, although the odds remain subject to movement before fight night.

Ciryl Gane vs. Josh Hokit: UFC 334 Heavyweight Title Fight

Ciryl Gane enters UFC 334 as the newly recognized undisputed UFC heavyweight champion and will make his first title defense against undefeated contender Josh Hokit.

According to the latest odds reported by Sherdog, Gane opened at -150 and had moved to -235, while Hokit was listed at +195. Those numbers reflect the market at the time of publication and are not a prediction of the fight’s outcome.

Gane owns a 14-2 record with one no-contest and most recently captured the interim heavyweight championship with a TKO victory over Alex Pereira at UFC Freedom 250. He was subsequently elevated to undisputed champion after Tom Aspinall vacated the heavyweight title.

Hokit presents an entirely different challenge.

The undefeated heavyweight is 10-0 and has quickly established himself as one of the division’s emerging contenders. His UFC record includes six knockout victories and three submission wins, while six of his professional victories have come in the opening round.

Hokit’s recent run includes a unanimous decision victory over Curtis Blaydes at UFC 327 and a second-round stoppage of Derrick Lewis at UFC Freedom 250.

That makes UFC 334 a significant test of experience versus momentum at heavyweight.

Kayla Harrison vs. Amanda Nunes: A Historic Women’s MMA Matchup

The UFC 334 co-main event could generate even more attention among women’s MMA fans.

Kayla Harrison will defend the UFC women’s bantamweight championship against Amanda Nunes, bringing together the current titleholder and a former two-division UFC champion.

Harrison enters the matchup with a 19-1 professional record. The two-time Olympic judo gold medalist won the UFC women’s bantamweight championship by submitting Julianna Peña at UFC 316. Before joining the UFC, Harrison won two PFL championship tournaments.

Nunes, meanwhile, returns to competition after stepping away from MMA in 2023.

The former UFC women’s bantamweight and featherweight champion owns a 23-5 professional record and is returning to face Harrison in a fight that was originally scheduled for UFC 324 before Harrison withdrew because of a neck injury.

The matchup also carries an interesting personal connection: Harrison and Nunes previously trained together at American Top Team.

UFC 334 Odds: Harrison vs. Nunes

The betting market has also moved toward Harrison since the matchup was initially announced.

Sherdog reported that Harrison opened at -155 against Nunes at +135 when the bout was first scheduled for UFC 324. The latest numbers cited by Sherdog had Harrison at -210 and Nunes at +175.

Another report published the following day showed different numbers, with Harrison at -180 and Nunes at +150, illustrating why UFC betting odds should be viewed as a constantly changing market rather than a fixed measurement.

Why UFC 334 Is More Than Just the Odds

While the betting lines provide one way to measure market expectations, the UFC 334 matchups have considerably more significance than their respective moneylines.

For Gane, the fight represents his first opportunity to establish himself as the undisputed heavyweight champion inside the Octagon.

For Hokit, it is a chance to become champion while preserving a perfect professional record.

For Harrison, UFC 334 marks her first defense of the UFC women’s bantamweight championship.

And for Nunes, it represents a return to active competition against one of the most accomplished athletes currently competing in women’s MMA.

The UFC itself has positioned the two title fights as the centerpiece of its return to Madison Square Garden.

UFC 334 Fight Card

The currently announced UFC 334 lineup includes:

Main Card

• Ciryl Gane vs. Josh Hokit — UFC Heavyweight Championship
• Kayla Harrison vs. Amanda Nunes — UFC Women’s Bantamweight Championship
• Caio Borralho vs. Yousri Belgaroui
• Uroš Medić vs. Kevin Holland
• Bilal Hasan vs. Luis Gurule

Preliminary Card

• Stephen Thompson vs. Charles Radtke
• Drew Dober vs. Chris Duncan
• Jim Miller vs. Terrance McKinney
• Donte Johnson vs. Baisangur Susurkaev
• Macy Chiasson vs. Bia Mesquita
• Adrian Yanez vs. Juan Diaz
• Nazim Sadykhov vs. Jefferson Nascimento

The UFC’s official event page currently lists the main card for 9 p.m. ET, with preliminary bouts scheduled earlier in the evening.

UFC 334 at Madison Square Garden

UFC 334 will be the promotion’s return to Madison Square Garden on November 14, 2026.

The venue has become an important stop on the UFC calendar, and the 2026 edition features championship fights in both heavyweight and women’s bantamweight divisions.

The card also includes the final UFC appearance of longtime veteran Stephen Thompson, who is scheduled to face Charles Radtke.

With an undefeated heavyweight challenger, a newly crowned heavyweight champion, a reigning women’s champion and the return of one of the most accomplished fighters in MMA history, UFC 334 has multiple storylines extending well beyond the current betting lines.

UFC 334 takes place November 14 at Madison Square Garden in New York City, with Ciryl Gane vs. Josh Hokit headlining and Kayla Harrison vs. Amanda Nunes serving as the co-main event.

Betting odds cited in this article are time-sensitive market prices and can change before the event. They are presented for informational purposes, not as predictions or wagering recommendations.